Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids
نویسندگان
چکیده
Lynnette Fernandez-Cuesta1,*, Martin Peifer1,2,*, Xin Lu1, Ruping Sun3, Luka Ozretić4, Danila Seidel1,5, Thomas Zander1,6,7, Frauke Leenders1,5, Julie George1, Christian Müller1, Ilona Dahmen1, Berit Pinther1, Graziella Bosco1, Kathryn Konrad8, Janine Altmüller8,9,10, Peter Nürnberg2,8,9, Viktor Achter11, Ulrich Lang11,12, Peter M. Schneider13, Magdalena Bogus13, Alex Soltermann14, Odd Terje Brustugun15,16, Åslaug Helland15,16, Steinar Solberg17, Marius Lund-Iversen18, Sascha Ansén6, Erich Stoelben19, Gavin M. Wright20, Prudence Russell21, Zoe Wainer20, Benjamin Solomon22, John K. Field23, Russell Hyde23, Michael P.A. Davies23, Lukas C. Heukamp4,7, Iver Petersen24, Sven Perner25, Christine M. Lovly26, Federico Cappuzzo27, William D. Travis28, Jürgen Wolf5,6,7, Martin Vingron3, Elisabeth Brambilla29, Stefan A. Haas3, Reinhard Buettner4,5,7 & Roman K. Thomas1,4,5
منابع مشابه
Frequent mutations in chromatin-remodeling genes in pulmonary carcinoids
Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and observe frequent mutations in chromatin-remodelling genes. Covalent histone modif...
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